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Section: Partnerships and Cooperations
National Initiatives
IHU LIRYC
Our work is partially funded by the LIRYC project (ANR 10-IAHU 04).
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For 2015: the salary of M. Potse, member of Carmen, is paid by LIRYC..
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For 2012-2015: 1/2 PhD thesis associated to the project Modélisation pour les données multimodales (see section Regional Initiaves).
ANR HR-CEM
In 2014, we are supported for the project “High Resolution Cardiac Electrophysiology Models: HR-CEM” within the call for project « Modèles Numériques » of the ANR.
The scientific start of the project was on November 4th, 2013.
It is an international project that involves three partners: Inria (coordinator), IHU LIRYC, and UMI-CRM at Montréal (Canada). The project has some external collaborators in Univ. Bordeaux and Univ. Pau.
Based on these collaborations and new developments in structural and functional imaging of the heart available at LIRYC, we plan to reconsider the concepts behind the models in order to improve the accuracy and efficiency of simulations. Cardiac simulation software and high-resolution numerical models will be derived from experimental data from animal models. Validation will be performed by comparing of simulation output with experimentally recorded functional data. The validated numerical models will be made available to the community of researchers who take advantage of in-silico cardiac simulation and, hopefully, become references. In particular we shall provide the first exhaustive model of an animal heart including the four chambers coupled through the special conduction network, with highly detailed microstructure of both the atria and the ventricles. Such a model embedded in high-performance computational software will provide stronger medical foundations for in-silico experimentation, and elucidate mechanisms of cardiac arrhythmias.
AMIES – Medic Activ
We were granted by the Agency AMIES a financial support to complete the one obtained from the Région Aquitaine for the Medic Activ project (see above). The objective of this support is to developp reduced order models of cardiac electrophysiology that might enter the MedicActiv framework. The difficulty is to define qualitatively realistic but fast numerical simulations of the ECG and cardiac function, for educational purpose.
ANR Labcom CardioXcomp
We are participant in the ANR Labcom project between Inria and the society Notocord (www.notocord.com ). At Inria, the proejct is leaded by J.-F. Gerbeau from the Reo team and we participate to the study and developpment of cardiac electrophysiology models suited to the context of the proejct.
The aim of CarioXcomp is to code human induced pluripotent cardiomyocyte cells and drug/hiPS-CMs interaction. N. Zemzemi works on this project with E. Abbate (PhD thesis until october 2015) for th coupling between human induced pluripotent cardiomyocyte cells and the measurement tool multi-electrode array (MEA). In this project, some different tests on drug models and selection of the most suitable for the hiPS-CMs. In the same time, N. Zemzemi with collaborators N. Fikal, R. Aboulaich and EL.M. El Guarmah worked on the quantification of the effect of uncertainty in the conductivity values on the Electrocardiography imaging (ECGI) inverse solution. N. Zemzemi and J. Lassoued C. Corrado and M. Mahjoub worked on the stability analyssis of the reduced order model for the bidomain equation using proper orthogonal decomposition and on the estimation of the location of cardiac isquemia in a 3D geometry with inverse problem tools with C. Chavez F. Alonso-Atienz, D. Alvarez and Y. Coudière.
REO
The CARMEN team is a partner with the REO team at Inria Paris Rocquencourt and the NOTOCORD company in the CardioXcomp project.
MedicActiv
The CARMEN team cooperates in interaction with the MedicActiV project.
GENCI
GENCI – grand équipement national de calcul intensif – is the agency that grants access to national high-performance resources for scientific purposes in France. GENCI projects have to be renewed yearly. Our project renewal Interaction between tissue structure and ion-channel function in cardiac arrhythmia, submitted in October 2015, has been granted 9.4 million core-hours on the three major systems Curie, Occigen, and Turing. This compute time, to be used in the calendar year 2016, is primarily destined for our research into the interaction between ionic and structural heart disease in atrial fibrillation, Brugada syndrome, and early repolarisation syndrome [37] .